Mondo Description A broad classification of inherited disorders presenting at birth that affect the cell-mediated aspect of the immune response. Circulating numbers of T lymphocytes are decreased or ineffective.

Disease Ontology Description A primary immunodeficiency disease that is characterized by decreased functioning of the T cells, which are drivers of cell-mediated immunity, resulting in increased susceptibility to intracellular bacterial, viral, and fungal infections, and has_material_basis_in a primary immunodeficiency or secondary to chronic infection, illness, or drugs.