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selective IgA deficiency disease

Disease Summary
Associated Targets (6)
Tbio

5

Tchem

1


Mondo Description A dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class A (IgA). It is the most common primary antibody deficiency. It may be inherited or the reversible sequela of infection or certain drugs. It may be caused by decreased or inefficient class-switching from progenitor B cells without any corresponding decreases in the other isotypes. Though affected persons may be asymptomatic, low levels of IgA will reduce the immune system's ability to combat infection where IgA is normally secreted, at mucosal surfaces. Selective IgA deficiency is seen in greater proportion among patients with autoimmune disorders.
Disease Ontology Description A selective immunoglobulin deficiency disease that is the result of a deficiency of immunoglobulin A (IgA), an antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract.
Mondo Term and Equivalent IDs
MONDO:0001341:  selective IgA deficiency disease
DC:0000223: 
EFO:1001929: 
MESH:D017098: 
NCIT:C26964: 
SCTID:29260007: 
UMLS:C0162538: 
UMLS:C4049006: