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Bartter disease type 1

Disease Summary
Associated Targets (3)
Tclin

1

Tchem

1

Tbio

1


GARD Rare
Uniprot Description A form of Bartter syndrome, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS1 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
Mondo Term and Equivalent IDs
MONDO:0100344:  Bartter disease type 1
GARD:0000830: 
MESH:C537652: 
SCTID:700107006: