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Barrett esophagus

Disease Summary
Associated Targets (216)
Tbio

146

Tchem

42

Tclin

15

Tdark

13


Mondo Description Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)
Uniprot Description A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
Mondo Term and Equivalent IDs
MONDO:0013662:  Barrett esophagus
COHD:443344: 
EFO:0000280: 
MESH:D001471: 
NCIT:C2891: 
SCTID:196609006: