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anaplastic astrocytoma

Disease Summary
Associated Targets (27)
Tchem

11

Tclin

10

Tbio

6


GARD Rare
Mondo Description Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord.
Disease Ontology Description An astrocytoma that is characterized by cells with regular, round to oval nuclei.
Mondo Term and Equivalent IDs
MONDO:0016684:  anaplastic astrocytoma
EFO:0002499: 
GARD:0005860: 
NCIT:C9477: 
ONCOTREE:AASTR: 
Orphanet:251589: 
UMLS:C0334579: