Pharos: uterine corpus leiomyoma (129 associated targets)

Disease Summary

Associated Targets (129)

Tbio

83

Tchem

20

Tdark

19

Tclin

7

Explore Associated Targets

Mondo Description

A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.

Disease Ontology Description

A uterine benign neoplasm derived from the smooth muscle layer of the uterus.

Mondo Term and Equivalent IDs

MONDO:0007886: uterine corpus leiomyoma

COHD:197236:

DOID:13223: uterine fibroid

EFO:0000731:

ICD9:218.9:

NCIT:C3434:

OMIM:150699: LEIOMYOMA, UTERINE

ONCOTREE:ULM:

SCTID:95315005:

UMLS:C0042133:

UMLS:C2242776:

GWAS Targets (143)

Explore on Target Illumination GWAS Analytics (TIGA)
trait: uterine fibroid

Items per page:

1 – 5 of 143

Target	TDL	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Nesprin-1 (SYNE1)	Tbio	2	3	0	1.2	92.9

Dynein heavy chain 2, axonemal (DNAH2)	Tbio	2	2	0	1.8	91.4

Mannose-P-dolichol utilization defect 1 protein (MPDU1)	Tbio	2	2	0	1.7	91.4

Macrosialin (CD68)	Tbio	2	2	0	1.7	91.4

Sentrin-specific protease 3 (SENP3)	Tbio	2	2	0	1.7	91.4

Explore on Target Illumination GWAS Analytics (TIGA)
trait: uterine fibroid

Items per page:

1 – 5 of 143

Target	TDL	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Nesprin-1 (SYNE1)	Tbio	0	1.2	92.9

Dynein heavy chain 2, axonemal (DNAH2)	Tbio	0	1.8	91.4

Mannose-P-dolichol utilization defect 1 protein (MPDU1)	Tbio	0	1.7	91.4

Macrosialin (CD68)	Tbio	0	1.7	91.4

Sentrin-specific protease 3 (SENP3)	Tbio	0	1.7	91.4