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tuberculosis

Disease Summary
Associated Targets (2499)
Tbio

1700

Tchem

348

Tdark

323

Tclin

128


Explore Associated Targets
Mondo Description A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use.
Disease Ontology Description A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
Mondo Term and Equivalent IDs
MONDO:0018076:  tuberculosis
COHD:434557: 
GARD:0007827: 
ICD10:A15.A19: 
MESH:D014376: 
NCIT:C3423: 
Orphanet:3389: 
SCTID:56717001: 
UMLS:C0041296: 
UMLS:C0151332: 
GWAS Targets (353)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
1
1
0
1.3
50.6
Tbio
1
1
0
1.3
50.6
Tclin
1
1
0
1.3
50.6
Tbio
1
1
0
1.3
50.6
Tdark
1
1
0
1.3
50.6
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
1.3
50.6
Tbio
0
1.3
50.6
Tclin
0
1.3
50.6
Tbio
0
1.3
50.6
Tdark
0
1.3
50.6
Disease Hierarchy
Target Novelty (Tin-x)
Too many associated targets