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transient myeloproliferative syndrome

Disease Summary
Associated Targets (3)
Tbio

2

Tchem

1


GARD Rare
Mondo Description A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission.
Disease Ontology Description A myeloproliferative neoplasm characterized by leukocytosis in newborns with Down syndrome and rarely in non-Down's infants.
Mondo Term and Equivalent IDs
MONDO:0008040:  transient myeloproliferative syndrome
GARD:0012765: 
MESH:C563551: 
NCIT:C82339: 
ONCOTREE:TAM: 
Orphanet:420611: 
SCTID:721307000: 
UMLS:C1834582: