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systemic lupus erythematosus

Disease Summary
Associated Targets (513)
Tbio

359

Tchem

65

Tdark

62

Tclin

27


Explore Associated Targets
Mondo Description An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.
Uniprot Description A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Disease Ontology Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.
Mondo Term and Equivalent IDs
MONDO:0007915:  systemic lupus erythematosus
COHD:257628: 
EFO:0002690: 
ICD9:710.0: 
MESH:D008180: 
NCIT:C3201: 
Orphanet:536: 
SCTID:55464009: 
GWAS Targets (790)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
17
14
0
1.6
99.5
Tchem
16
10
0
1.5
99.5
Tchem
16
10
0
1.5
99.5
Tdark
15
12
0
1.6
99.5
Tbio
15
12
0
1.6
99.5
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
1.6
99.5
Tchem
0
1.5
99.5
Tchem
0
1.5
99.5
Tdark
0
1.6
99.5
Tbio
0
1.6
99.5
Disease Hierarchy
Target Novelty (Tin-x)