Pharos: squamous cell carcinoma (844 associated targets)

Disease Summary

Associated Targets (844)

Tbio

548

Tchem

152

Tdark

89

Tclin

55

Explore Associated Targets

Mondo Description

A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma.

Disease Ontology Description

A carcinoma that derives_from squamous epithelial cells.

Mondo Term and Equivalent IDs

MONDO:0005096: squamous cell carcinoma

DOID:1749: squamous cell carcinoma

EFO:0000707:

GARD:0001091:

MESH:D002294:

NCIT:C2929:

SCTID:402815007:

UMLS:C0007137:

GWAS Targets (177)

Items per page:

1 – 5 of 177

Target	TDL	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Transcription factor 25 (TCF25)	Tbio	3	3	0	1.3	96.2

Dysbindin domain-containing protein 1 (DBNDD1)	Tdark	3	3	0	1.3	96.2

Protein spire homolog 2 (SPIRE2)	Tbio	3	3	0	1.3	96.2

Melanocyte-stimulating hormone receptor (MC1R)	Tclin	3	3	0	1.3	96.2

Differentially expressed in FDCP 8 homolog (DEF8)	Tdark	3	3	0	1.3	96.2

Items per page:

1 – 5 of 177

Target	TDL	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Transcription factor 25 (TCF25)	Tbio	0	1.3	96.2

Dysbindin domain-containing protein 1 (DBNDD1)	Tdark	0	1.3	96.2

Protein spire homolog 2 (SPIRE2)	Tbio	0	1.3	96.2

Melanocyte-stimulating hormone receptor (MC1R)	Tclin	0	1.3	96.2

Differentially expressed in FDCP 8 homolog (DEF8)	Tdark	0	1.3	96.2