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sick sinus syndrome 1

Disease Summary
Associated Targets (1)
Tclin

1


Mondo Description Any sick sinus syndrome in which the cause of the disease is a mutation in the SCN5A gene.
Uniprot Description The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS1 onset is in utero, infancy, or early childhood.
Mondo Term and Equivalent IDs
MONDO:0024562:  sick sinus syndrome 1