Pharos: sclerosing cholangitis (84 associated targets)

Disease Summary

Associated Targets (84)

Tbio

53

Tchem

17

Tdark

9

Tclin

5

Explore Associated Targets

Mondo Description

A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Mondo Term and Equivalent IDs

MONDO:0018646: sclerosing cholangitis

DOID:14268: sclerosing cholangitis

EFO:0004268:

NCIT:C4828:

Orphanet:447771:

SCTID:235917005:

UMLS:C0008313:

GWAS Targets (86)

Items per page:

1 – 5 of 86

Target	TDL	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Protein bassoon (BSN)	Tbio	3	1	0	1.3	77.7

Mannose-1-phosphate guanyltransferase beta (GMPPB)	Tbio	3	1	0	1.3	77.7

Hepatocyte growth factor-like protein (MST1)	Tchem	3	1	0	1.3	77.7

E3 ubiquitin-protein ligase RNF123 (RNF123)	Tbio	3	1	0	1.3	77.7

Inositol hexakisphosphate kinase 1 (IP6K1)	Tbio	3	1	0	1.3	77.7

Items per page:

1 – 5 of 86

Target	TDL	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Protein bassoon (BSN)	Tbio	0	1.3	77.7

Mannose-1-phosphate guanyltransferase beta (GMPPB)	Tbio	0	1.3	77.7

Hepatocyte growth factor-like protein (MST1)	Tchem	0	1.3	77.7

E3 ubiquitin-protein ligase RNF123 (RNF123)	Tbio	0	1.3	77.7

Inositol hexakisphosphate kinase 1 (IP6K1)	Tbio	0	1.3	77.7