Pharos: primary biliary cholangitis (202 associated targets)

Disease Summary

Associated Targets (202)

Tbio

131

Tchem

37

Tclin

18

Tdark

16

Explore Associated Targets

Mondo Description

Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Disease Ontology Description

A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.

Mondo Term and Equivalent IDs

MONDO:0005388: primary biliary cholangitis

COHD:4135822:

DOID:12236: primary biliary cirrhosis

EFO:0004267:

GARD:0007459:

MESH:D008105:

NCIT:C27167:

OMIMPS:109720:

Orphanet:186:

SCTID:31712002:

UMLS:C0008312:

GWAS Targets (413)

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1 – 5 of 413

Target	TDL	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Interleukin-12 receptor subunit beta-2 (IL12RB2)	Tbio	3	2	0	1.5	83.7

Interleukin-23 receptor (IL23R)	Tchem	3	2	0	1.5	83.7

Plasminogen activator inhibitor 1 RNA-binding protein (SERBP1)	Tbio	3	2	0	1.5	83.7

Interleukin-12 subunit alpha (IL12A)	Tclin	3	2	0	1.4	78.7

Transportin-3 (TNPO3)	Tbio	2	2	0	1.6	72.6

Items per page:

1 – 5 of 413

Target	TDL	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Interleukin-12 receptor subunit beta-2 (IL12RB2)	Tbio	0	1.5	83.7

Interleukin-23 receptor (IL23R)	Tchem	0	1.5	83.7

Plasminogen activator inhibitor 1 RNA-binding protein (SERBP1)	Tbio	0	1.5	83.7

Interleukin-12 subunit alpha (IL12A)	Tclin	0	1.4	78.7

Transportin-3 (TNPO3)	Tbio	0	1.6	72.6