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plasma cell myeloma

Disease Summary
Associated Targets (1423)
Tbio

1052

Tchem

190

Tdark

93

Tclin

88


Explore Associated Targets
Mondo Description A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)
Uniprot Description A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Disease Ontology Description A myeloid neoplasm that is located in the plasma cells in bone marrow.
Mondo Term and Equivalent IDs
MONDO:0009693:  plasma cell myeloma
COHD:437233: 
EFO:0001378: 
GARD:0007108: 
ICD10:C90.0: 
MESH:D009101: 
NCIT:C3242: 
ONCOTREE:PCM: 
Orphanet:29073: 
UMLS:C0026764: 
GWAS Targets (103)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tchem
3
3
0
1.2
91.4
Tbio
3
3
0
1.2
91.4
Tbio
3
3
0
1.2
91.4
Tchem
3
3
0
1.2
91.4
Tbio
2
2
0
1.2
88.7
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tchem
0
1.2
91.4
Tbio
0
1.2
91.4
Tbio
0
1.2
91.4
Tchem
0
1.2
91.4
Tbio
0
1.2
88.7
Target Novelty (Tin-x)