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pityriasis rubra pilaris

Disease Summary
Associated Targets (3)
Tbio

2

Tchem

1


Uniprot Description A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.
DataSource References
eRAM:  DOID:9212
CTD:  DOID:9212
UniProt Disease:  MIM:173200
Monarch:  OMIM:173200
DisGeNET:  UMLS:C0032027
Disease Hierarchy
Parents
Tbio

4566

Tdark

1172

Tchem

884

Tclin

307

Children
Target Novelty (Tin-x)