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paraplegia-intellectual disability-hyperkeratosis syndrome

Disease Summary
Associated Targets ()

Mondo Description Paraplegia-intellectual disability-hyperkeratosis syndrome is characterized by intellectual deficit, spasticity in the lower limbs (spastic paraplegia), pes cavus deformity of both feet, an abnormal gait, and palmar and plantar hyperkeratosis. It has been reported in four brothers. The mother of the affected boys had normal intelligence, plantar hyperkeratosis and a strong facial resemblance to her retarded sons. Her three daughters were normal. This syndrome most likely an X-linked recessive condition.
Mondo Term and Equivalent IDs
MONDO:0010662:  paraplegia-intellectual disability-hyperkeratosis syndrome
GARD:0002344: 
MESH:C537058: 
Orphanet:2824: 
UMLS:C2745996: