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osteoporosis

Disease Summary
Associated Targets (122)
Tbio

65

Tchem

32

Tclin

19

Tdark

6


Explore Associated Targets
Mondo Description A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).
Uniprot Description A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.
Disease Ontology Description A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.
Mondo Term and Equivalent IDs
MONDO:0005298:  osteoporosis
COHD:80502: 
EFO:0003882: 
GARD:0011932: 
ICD10:M81: 
ICD9:733.00: 
MESH:D010024: 
NCIT:C3298: 
SCTID:64859006: 
GWAS Targets (22)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tdark
1
1
0
2.3
33.1
Tdark
1
1
0
2.3
33.1
Tbio
1
1
0
2.3
33.1
Tchem
1
1
0
10.2
33.1
Tbio
1
1
0
2.3
33.1
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tdark
0
2.3
33.1
Tdark
0
2.3
33.1
Tbio
0
2.3
33.1
Tchem
0
10.2
33.1
Tbio
0
2.3
33.1
Target Novelty (Tin-x)