Pharos: open-angle glaucoma (134 associated targets)

Disease Summary

Associated Targets (134)

Tbio

75

Tclin

32

Tchem

15

Tdark

12

Explore Associated Targets

Mondo Description

Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

Disease Ontology Description

A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.

Mondo Term and Equivalent IDs

MONDO:0005338: open-angle glaucoma

COHD:441284:

DOID:1067: open-angle glaucoma

EFO:0004190:

ICD9:365.10:

ICD9:365.13:

MESH:D005902:

NCIT:C34641:

SCTID:46168003:

SCTID:84494001:

UMLS:C0017612:

GWAS Targets (106)

Items per page:

1 – 5 of 106

Target	TDL	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	Tbio	10	9	0	1.3	98.1

Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	Tbio	10	9	0	1.3	98.1

Tumor suppressor ARF (CDKN2A)	Tbio	10	9	0	1.3	98.1

4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)	Tbio	4	3	0	1.4	94.5

Calcium load-activated calcium channel (TMCO1)	Tbio	4	3	0	1.4	94.5

Items per page:

1 – 5 of 106

Target	TDL	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	Tbio	0	1.3	98.1

Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	Tbio	0	1.3	98.1

Tumor suppressor ARF (CDKN2A)	Tbio	0	1.3	98.1

4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)	Tbio	0	1.4	94.5

Calcium load-activated calcium channel (TMCO1)	Tbio	0	1.4	94.5