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diabetes mellitus

Disease Summary
Associated Targets (3667)
Tbio

2337

Tdark

654

Tchem

474

Tclin

202


Explore Associated Targets
Mondo Description A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.
Disease Ontology Description A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
Mondo Term and Equivalent IDs
MONDO:0005015:  diabetes mellitus
COHD:201820: 
DOID:9351: diabetes mellitus
EFO:0000400: 
ICD10:E10.E14: 
MESH:D003920: 
NCIT:C2985: 
SCTID:73211009: 
UMLS:C0011847: 
UMLS:C0011849: 
GWAS Targets (3)
Items per page:
1 – 3 of 3
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid adenoma-associated protein (THADA)
Tbio
1
1
0
7.6
14.2
C1GALT1-specific chaperone 1-like protein (C1GALT1C1L)
Tdark
1
1
0
7.6
14.2
Pleckstrin homology domain-containing family H member 2 (PLEKHH2)
Tdark
1
1
0
7.6
14.2
Items per page:
1 – 3 of 3
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid adenoma-associated protein (THADA)
Tbio
0
7.6
14.2
C1GALT1-specific chaperone 1-like protein (C1GALT1C1L)
Tdark
0
7.6
14.2
Pleckstrin homology domain-containing family H member 2 (PLEKHH2)
Tdark
0
7.6
14.2
Disease Hierarchy
Parents
endocrine pancreas disease (3718)
Tbio

2346

Tdark

654

Tchem

502

Tclin

216

glucose metabolism disease (3697)
Tbio

2355

Tdark

654

Tchem

480

Tclin

208

Children
type 2 diabetes mellitus (2446)
Tbio

1587

Tdark

391

Tchem

309

Tclin

159

type 1 diabetes mellitus (390)
Tbio

288

Tchem

43

Tdark

32

Tclin

27

maturity-onset diabetes of the young (161)
Tbio

91

Tchem

46

Tclin

21

Tdark

3

maturity-onset diabetes of the young (161)
Tbio

91

Tchem

46

Tclin

21

Tdark

3

gestational diabetes (18)
Tbio

8

Tclin

6

Tchem

4

neonatal diabetes mellitus (11)
Tbio

7

Tclin

2

Tchem

2

hereditary chronic pancreatitis (6)
Tchem

3

Tclin

2

Tbio

1

hereditary chronic pancreatitis (6)
Tchem

3

Tclin

2

Tbio

1

Berardinelli-Seip congenital lipodystrophy (3)
Tbio

2

Tchem

1

microcephalic primordial dwarfism-insulin resistance syndrome (2)
Tbio

2

Wolcott-Rallison syndrome (1)
Tchem

1

Wolcott-Rallison syndrome (1)
Tchem

1

Woodhouse-Sakati syndrome (1)
Tbio

1

Woodhouse-Sakati syndrome (1)
Tbio

1

Donohue syndrome (1)
Tclin

1

thiamine-responsive megaloblastic anemia syndrome (1)
Tbio

1

thiamine-responsive megaloblastic anemia syndrome (1)
Tbio

1

Rabson-Mendenhall syndrome (1)
Tclin

1

SHORT syndrome (1)
Tchem

1

pancreatic hypoplasia-diabetes-congenital heart disease syndrome (1)
Tbio

1

pancreatic hypoplasia-diabetes-congenital heart disease syndrome (1)
Tbio

1

insulin-resistance syndrome type A (1)
Tclin

1

congenital generalized lipodystrophy type 4 (1)
Tbio

1

PLIN1-related familial partial lipodystrophy (1)
Tbio

1

polyendocrine-polyneuropathy syndrome (1)
Tbio

1

juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome (1)
Tbio

1

juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome (1)
Tbio

1

laminopathy type Decaudain-Vigouroux (1)
Tbio

1

acquired generalized lipodystrophy (1)
Tclin

1

prediabetes syndrome (0)
stiff-person syndrome (0)
acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome (0)
AREDYLD syndrome (0)
AREDYLD syndrome (0)
myopathy and diabetes mellitus (0)
myopathy and diabetes mellitus (0)
maternally-inherited diabetes and deafness (0)
maternally-inherited diabetes and deafness (0)
monogenic diabetes (0)
insulin-resistance syndrome type B (0)
autosomal semi-dominant severe lipodystrophic laminopathy (0)
primary microcephaly-mild intellectual disability-young-onset diabetes syndrome (0)
intrauterine growth restriction-short stature-early adult-onset diabetes syndrome (0)
short fifth metacarpals-insulin resistance syndrome (0)
Target Novelty (Tin-x)
Too many associated targets