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chronic obstructive pulmonary disease

Disease Summary
Associated Targets (883)
Tbio

579

Tchem

143

Tdark

92

Tclin

69


Explore Associated Targets
Mondo Description A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.
Mondo Term and Equivalent IDs
MONDO:0005002:  chronic obstructive pulmonary disease
COHD:255573: 
DOID:3083: chronic obstructive pulmonary disease
EFO:0000341: 
MESH:D029424: 
NCIT:C3199: 
SCTID:13645005: 
GWAS Targets (2081)
Items per page:
1 – 5 of 2081
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)
Tbio
14
12
4
1.3
99.3
Proteasome subunit alpha type-4 (PSMA4)
Tbio
14
12
4
1.3
99.3
Hydroxylysine kinase (HYKK)
Tbio
14
12
4
1.3
99.3
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)
Tclin
13
11
4
1.3
99.3
Iron-responsive element-binding protein 2 (IREB2)
Tbio
8
7
2
1.3
99.2
Items per page:
1 – 5 of 2081
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)
Tbio
4
1.3
99.3
Proteasome subunit alpha type-4 (PSMA4)
Tbio
4
1.3
99.3
Hydroxylysine kinase (HYKK)
Tbio
4
1.3
99.3
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)
Tclin
4
1.3
99.3
Iron-responsive element-binding protein 2 (IREB2)
Tbio
2
1.3
99.2
Target Novelty (Tin-x)