You are using an outdated browser. Please upgrade your browser to improve your experience.

celiac disease

Disease Summary
Associated Targets (194)
Tbio

130

Tchem

29

Tdark

27

Tclin

8


Explore Associated Targets
Mondo Description An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.
Disease Ontology Description An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.
Mondo Term and Equivalent IDs
MONDO:0005130:  celiac disease
COHD:194992: 
EFO:0001060: 
GARD:0011998: 
ICD10:K90.0: 
ICD9:579.0: 
MESH:D002446: 
NCIT:C26714: 
OMIMPS:212750: 
SCTID:396331005: 
UMLS:C0007570: 
GWAS Targets (279)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
5
4
1
1.4
93.4
Tclin
5
4
1
1.4
93.4
Tbio
4
2
0
1.3
93.1
Tbio
4
4
2
1.5
93
Tchem
5
6
1
1.3
90.8
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
1
1.4
93.4
Tclin
1
1.4
93.4
Tbio
0
1.3
93.1
Tbio
2
1.5
93
Tchem
1
1.3
90.8
Disease Hierarchy
Target Novelty (Tin-x)