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acute myeloid leukemia

Disease Summary
Associated Targets (1014)
Tbio

660

Tchem

182

Tdark

99

Tclin

73


GARD Rare
Mondo Description Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.
Uniprot Description A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
Disease Ontology Description A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
Mondo Term and Equivalent IDs
MONDO:0018874:  acute myeloid leukemia
EFO:0000222: 
GARD:0000537: 
GARD:0012757: 
ICD9:205.00: 
MESH:D015470: 
NCIT:C3171: 
ONCOTREE:AML: 
Orphanet:519: 
SCTID:91861009: 
UMLS:C0023467: