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Vitiligo

Disease Summary
Associated Targets (281)
Tbio

202

Tchem

39

Tdark

28

Tclin

12


Uniprot Description A pigmentary disorder of the skin and mucous membranes. It is characterized by circumscribed depigmented macules and patches, commonly on extensor aspects of extremities, on the face or neck and in skin folds. Vitiligo is a progressive disorder in which some or all of the melanocytes in the affected skin are selectively destroyed. It is a multifactorial disorder with a complex etiology probably including autoimmune mechanisms, and is associated with an elevated risk of other autoimmune diseases.
Disease Ontology Description An autoimmune hypersensitivity disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.
DataSource References
JensenLab Experiment TIGA:  DOID:12306
CTD:  DOID:12306
JensenLab Knowledge MedlinePlus:  DOID:12306
JensenLab Text Mining:  DOID:12306
UniProt Disease:  MIM:193200
DisGeNET:  UMLS:C0042900
GWAS Targets (2377)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tchem
4
3
0
1.8
95.7
Tbio
2
2
0
3
93.2
Tbio
2
2
0
3
93.2
Tbio
2
2
0
3
93.2
Tbio
2
2
0
3
93.2
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tchem
0
1.8
95.7
Tbio
0
3
93.2
Tbio
0
3
93.2
Tbio
0
3
93.2
Tbio
0
3
93.2
Target Novelty (Tin-x)