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Systemic lupus erythematosus

Disease Summary
Associated Targets (132)
Tbio

99

Tchem

18

Tclin

12

Tdark

3


Uniprot Description A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Disease Ontology Description A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.
DataSource References
CTD: DOID:9074
Monarch: DOID:9074
DrugCentral Indication: DOID:9074
JensenLab Knowledge GHR: DOID:9074
JensenLab Knowledge UniProtKB-KW: DOID:9074
Expression Atlas: DOID:9074
JensenLab Knowledge AmyCo: DOID:9074
UniProt Disease: MIM:152700
Monarch: OMIM:152700
GWAS Targets (218)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
16
10
0
1.5
99.8
Tbio
11
6
0
1.7
99.5
Tbio
6
4
0
1.6
99.2
Tbio
9
5
0
1.3
98.9
Tbio
7
3
0
1.8
98.4
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
1.5
99.8
Tbio
0
1.7
99.5
Tbio
0
1.6
99.2
Tbio
0
1.3
98.9
Tbio
0
1.8
98.4
Target Novelty (Tin-x)