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Schizophrenia

Disease Summary
Associated Targets (1101)
Tbio

695

Tchem

203

Tclin

158

Tdark

45


Uniprot Description A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Disease Ontology Description A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.
DataSource References
DisGeNET: C0036341
JensenLab Text Mining: DOID:5419
DrugCentral Indication: DOID:5419
CTD: DOID:5419
JensenLab Knowledge GHR: DOID:5419
Expression Atlas: DOID:5419
Monarch: DOID:5419
UniProt Disease: MIM:181500
Monarch: OMIM:181500
GWAS Targets (1989)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
8
5
1
1.1
98.8
Tbio
5
4
0
1.1
98.7
Tbio
8
6
0
1.1
98.6
Tclin
11
7
1
1.1
98.2
Tclin
11
7
1
1.1
98.2
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
1
1.1
98.8
Tbio
0
1.1
98.7
Tbio
0
1.1
98.6
Tclin
1
1.1
98.2
Tclin
1
1.1
98.2
Target Novelty (Tin-x)