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Rheumatoid arthritis

Disease Summary
Associated Targets (1526)
Tbio

1065

Tchem

246

Tdark

137

Tclin

78


Uniprot Description An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Disease Ontology Description An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.
DataSource References
eRAM:  DOID:7148
Expression Atlas:  DOID:7148
JensenLab Experiment TIGA:  DOID:7148
DrugCentral Indication:  DOID:7148
CTD:  DOID:7148
JensenLab Knowledge AmyCo:  DOID:7148
JensenLab Knowledge MedlinePlus:  DOID:7148
Monarch:  DOID:7148
JensenLab Text Mining:  DOID:7148
UniProt Disease:  MIM:180300
Monarch:  OMIM:180300
DisGeNET:  UMLS:C0003873
GWAS Targets (2270)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
15
13
6
2.2
99.8
Tbio
15
13
12
2.2
99.8
Tbio
15
13
18
2.2
99.8
Tbio
15
13
12
2.2
99.8
Tbio
15
13
18
2.2
99.8
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
6
2.2
99.8
Tbio
12
2.2
99.8
Tbio
18
2.2
99.8
Tbio
12
2.2
99.8
Tbio
18
2.2
99.8
Target Novelty (Tin-x)