Pharos: Paget's disease of bone (15 associated targets)

Disease Summary

Associated Targets (15)

Tbio

11

Tclin

3

Tchem

1

Disease Ontology Description

A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

DataSource References

DrugCentral Indication: DOID:5408

CTD: DOID:5408

JensenLab Text Mining: DOID:5408

JensenLab Knowledge GHR: DOID:5408

GWAS Targets (8)

Items per page:

1 – 5 of 8

Target	TDL	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Optineurin (OPTN)	Tbio	2	1	0	1.6	96.2

Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)	Tbio	2	2	0	1.5	93.6

Dihydropyrimidinase (DPYS)	Tbio	1	1	0	1.4	80.1

Dendritic cell-specific transmembrane protein (DCSTAMP)	Tbio	1	1	0	1.4	80.1

Protein PML (PML)	Tbio	1	1	0	1.3	76.1

Items per page:

1 – 5 of 8

Target	TDL	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
Optineurin (OPTN)	Tbio	0	1.6	96.2

Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)	Tbio	0	1.5	93.6

Dihydropyrimidinase (DPYS)	Tbio	0	1.4	80.1

Dendritic cell-specific transmembrane protein (DCSTAMP)	Tbio	0	1.4	80.1

Protein PML (PML)	Tbio	0	1.3	76.1

Beta Count

Odds Ratio

Disease Hierarchy

Parents

hyperostosis (22)

Tbio

16

Tclin

4

Tchem

2

Children

Target Novelty (Tin-x)