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Osteoporosis

Disease Summary
Associated Targets (98)
Tbio

63

Tchem

15

Tclin

14

Tdark

6


Uniprot Description A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.
Disease Ontology Description A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.
DataSource References
CTD:  DOID:11476
JensenLab Text Mining:  DOID:11476
JensenLab Experiment TIGA:  DOID:11476
Monarch:  DOID:11476
DrugCentral Indication:  DOID:11476
UniProt Disease:  MIM:166710
Monarch:  OMIM:166710
DisGeNET:  UMLS:C0029456
GWAS Targets (22)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tdark
1
1
0
2.3
33.1
Tdark
1
1
0
2.3
33.1
Tbio
1
1
0
2.3
33.1
Tchem
1
1
0
10.2
33.1
Tbio
1
1
0
2.3
33.1
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tdark
0
2.3
33.1
Tdark
0
2.3
33.1
Tbio
0
2.3
33.1
Tchem
0
10.2
33.1
Tbio
0
2.3
33.1
Target Novelty (Tin-x)