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Multiple sclerosis

Disease Summary
Associated Targets (253)
Tbio

138

Tclin

71

Tchem

31

Tdark

13


Uniprot Description A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Disease Ontology Description A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
DataSource References
DisGeNET: C0026769
Monarch: DOID:2377
CTD: DOID:2377
JensenLab Knowledge GHR: DOID:2377
DrugCentral Indication: DOID:2377
Expression Atlas: DOID:2377
JensenLab Text Mining: DOID:2377
UniProt Disease: MIM:126200
GWAS Targets (338)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
8
4
18
2.6
99.5
Tbio
8
4
18
2.6
99.5
Tbio
8
4
18
2.6
99.5
Tbio
8
4
18
2.6
99.5
Tbio
8
4
18
2.6
99.5
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
18
2.6
99.5
Tbio
18
2.6
99.5
Tbio
18
2.6
99.5
Tbio
18
2.6
99.5
Tbio
18
2.6
99.5
Target Novelty (Tin-x)