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multiple sclerosis

Disease Summary
Associated Targets (893)
Tbio

582

Tdark

110

Tchem

105

Tclin

96


Mondo Description A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
Uniprot Description A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Disease Ontology Description A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Mondo Term and Equivalent IDs
MONDO:0005301:  multiple sclerosis
COHD:374919: 
EFO:0003885: 
ICD10:G35: 
MESH:D009103: 
NCIT:C3243: 
SCTID:24700007: 
UMLS:C0026769: 
GWAS Targets (1385)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
5
7
0
2.2
99.4
Tbio
5
7
0
2.2
99.4
Tchem
5
7
0
2.2
99.4
Tbio
5
7
0
2.2
99.4
Tbio
5
7
0
2.2
99.4
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
2.2
99.4
Tbio
0
2.2
99.4
Tchem
0
2.2
99.4
Tbio
0
2.2
99.4
Tbio
0
2.2
99.4
Target Novelty (Tin-x)