You are using an outdated browser. Please upgrade your browser to improve your experience.

Multiple myeloma

Disease Summary
Associated Targets (1360)
Tbio

1058

Tchem

134

Tdark

88

Tclin

80


Uniprot Description A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Disease Ontology Description A myeloid neoplasm that is located in the plasma cells in bone marrow.
DataSource References
DisGeNET: C0026764
eRAM: DOID:9538
Expression Atlas: DOID:9538
CTD: DOID:9538
DrugCentral Indication: DOID:9538
JensenLab Knowledge GHR: DOID:9538
JensenLab Text Mining: DOID:9538
UniProt Disease: MIM:254500
GWAS Targets (33)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tchem
3
3
0
1.2
98.2
Tbio
3
4
0
1.4
97.1
Tbio
3
2
0
1.3
95
Tbio
2
1
0
1.4
87.4
Tbio
1
1
0
1.2
79.9
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tchem
0
1.2
98.2
Tbio
0
1.4
97.1
Tbio
0
1.3
95
Tbio
0
1.4
87.4
Tbio
0
1.2
79.9
Target Novelty (Tin-x)