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Fuchs' endothelial dystrophy

Disease Summary
Associated Targets (10)
Tbio

7

Tdark

2

Tclin

1


Explore Associated Targets
Mondo Description Fuchs endothelial corneal dystrophy (FECD) is the most frequent form of posterior corneal dystrophy and is characterized by excrescences on a thickened Descemet membrane (corneal guttae), generalized corneal edema, with gradually decreased visual acuity.
Disease Ontology Description A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.
Mondo Term and Equivalent IDs
MONDO:0005321:  Fuchs' endothelial dystrophy
DC:0000643: 
EFO:0003946: 
MESH:D005642: 
NCIT:C84721: 
OMIMPS:136800: 
Orphanet:98974: 
SCTID:193839007: 
UMLS:C0016781: 
UMLS:CN207231: 
GWAS Targets (6)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
2
2
0
5.2
88.3
Tbio
1
1
0
1.4
65.5
Tbio
1
1
0
1.4
65.5
Tdark
1
1
0
2.1
62.1
Tbio
1
1
0
1.4
27.2
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
5.2
88.3
Tbio
0
1.4
65.5
Tbio
0
1.4
65.5
Tdark
0
2.1
62.1
Tbio
0
1.4
27.2
Disease Hierarchy
Target Novelty (Tin-x)