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Ewing sarcoma

Disease Summary
Associated Targets (25)
Tbio

19

Tchem

4

Tclin

1

Tdark

1


Explore Associated Targets
Mondo Description A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.
Uniprot Description A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Disease Ontology Description A bone cancer that has_material_basis in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.
Mondo Term and Equivalent IDs
MONDO:0012817:  Ewing sarcoma
EFO:0000174: 
GARD:0006390: 
MESH:D012512: 
NCIT:C4817: 
ONCOTREE:ES: 
Orphanet:319: 
UMLS:C0553580: 
GWAS Targets (12)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
1
1
0
1.7
68
Tbio
1
1
0
1.7
68
Tchem
1
1
0
2.2
30.1
Tchem
1
1
0
2.2
30.1
Tchem
1
1
0
2.2
30.1
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
1.7
68
Tbio
0
1.7
68
Tchem
0
2.2
30.1
Tchem
0
2.2
30.1
Tchem
0
2.2
30.1
Target Novelty (Tin-x)