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Colorectal cancer

Disease Summary
Associated Targets (1022)
Tbio

677

Tchem

155

Tdark

121

Tclin

69


Uniprot Description A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Disease Ontology Description A large intestine cancer that is located_in the colon and/or located_in the rectum.
DataSource References
JensenLab Experiment TIGA:  DOID:9256
JensenLab Text Mining:  DOID:9256
CTD:  DOID:9256
UniProt Disease:  MIM:114500
DisGeNET:  UMLS:C1527249
GWAS Targets (1161)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
14
5
0
1.2
98.4
Tbio
14
5
0
1.2
98.4
Tbio
17
5
0
1.2
98.1
Tbio
8
9
0
1.1
97.2
Tbio
8
8
0
1.1
97.1
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
1.2
98.4
Tbio
0
1.2
98.4
Tbio
0
1.2
98.1
Tbio
0
1.1
97.2
Tbio
0
1.1
97.1
Target Novelty (Tin-x)