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Asthma

Disease Summary
Associated Targets (207)
Tbio

115

Tchem

47

Tclin

38

Tdark

7


Uniprot Description The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Disease Ontology Description A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.
DataSource References
DisGeNET: C0004096
CTD: DOID:2841
DrugCentral Indication: DOID:2841
JensenLab Knowledge UniProtKB-KW: DOID:2841
JensenLab Text Mining: DOID:2841
Monarch: DOID:2841
Expression Atlas: DOID:2841
UniProt Disease: MIM:600807
GWAS Targets (1629)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
10
8
1
1.1
99.8
Tbio
16
9
1
1.2
99.8
Tbio
13
13
0
1.2
99.7
Tbio
15
7
1
1.2
99.7
Tbio
11
8
0
1.1
99.6
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
1
1.1
99.8
Tbio
1
1.2
99.8
Tbio
0
1.2
99.7
Tbio
1
1.2
99.7
Tbio
0
1.1
99.6
Target Novelty (Tin-x)