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Alzheimer's disease

Disease Summary
Associated Targets (434)
Tbio

303

Tchem

65

Tclin

33

Tdark

33


Disease Ontology Description A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
DataSource References
DisGeNET: C0002395
Expression Atlas: DOID:10652
JensenLab Knowledge UniProtKB-KW: DOID:10652
JensenLab Knowledge AmyCo: DOID:10652
DrugCentral Indication: DOID:10652
CTD: DOID:10652
Monarch: DOID:10652
JensenLab Text Mining: DOID:10652
eRAM: DOID:10652
JensenLab Knowledge GHR: DOID:10652
GWAS Targets (422)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
11
17
0
2
100
Tbio
14
6
3
3.1
99.9
Tbio
5
4
0
3.3
99.8
Tbio
14
6
0
1.2
99.8
Tbio
6
15
0
3.2
99.2
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
0
2
100
Tbio
3
3.1
99.9
Tbio
0
3.3
99.8
Tbio
0
1.2
99.8
Tbio
0
3.2
99.2
Target Novelty (Tin-x)