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Alzheimer disease

Disease Summary
Associated Targets (738)
Tbio

486

Tchem

108

Tdark

100

Tclin

44


Explore Associated Targets
Mondo Description A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Uniprot Description Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.
Disease Ontology Description A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Mondo Term and Equivalent IDs
MONDO:0004975:  Alzheimer disease
COHD:378419: 
EFO:0000249: 
ICD10:G30: 
MESH:D000544: 
NCIT:C2866: 
SCTID:142811000119104: 
UMLS:C0002395: 
GWAS Targets (570)
Target
TDL
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
27
66
2
2.8
99.9
Tbio
27
65
2
2.8
99.9
Tbio
27
64
2
2.7
99.9
Tbio
27
64
2
2.8
99.9
Tbio
27
63
2
2.7
99.9
Target
TDL
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Tbio
2
2.8
99.9
Tbio
2
2.8
99.9
Tbio
2
2.7
99.9
Tbio
2
2.8
99.9
Tbio
2
2.7
99.9
Target Novelty (Tin-x)